| 摘要 |
Compositions and methods to improve energy metabolism; increase levels of ATP; reduce or delay insulin resistance; control the blood levels of glucose, insulin, triglycerides, free fatty acids, cholesterol, or combinations thereof; reduce weight gain; improve cognitive function and mental acuity; improve memory or retention of memories; increase physical activity; improve endurance; reduce or prevent an increase in the ratio of fibrous tissue to muscle (as also referred to as the fibrous tissue : muscle ratio); reduce or prevent an increase in inflammation, such as chronic or acute inflammation; reduce amyloid blockage of mitochondrial respiration, or combinations thereof in a subject are disclosed. Typically, the methods include administering a therapeutically effective amount of a pharmaceutical composition comprising a fusion polypeptide and a pharmaceutically acceptable carrier to a subject. The compositions and methods can be used to treat or prevent age-related disorders or a symptom or co-morbidity thereof. |
