FORMULATION COMPRISING ANTISENSE NUCLEOTIDE TO CONNEXIN

摘要

PROBLEM TO BE SOLVED: To provide a formulation that is used in therapeutic and/or cosmetic treatment and comprises at least one anti-sense polynucleotide to a connexin protein together with a pharmaceutically acceptable carrier or vehicle.SOLUTION: The connexin 43 anti-sense polynucleotide comprises a specific sequence or a sequence having at least 90% identity to the sequence and has length of 40 nucleotides or less. The formulation comprises the polynucleotide together with a pharmaceutically acceptable carrier or vehicle and is useful in therapeutic and/or cosmetic treatment in which a localized disruption in direct cell-cell communication is desirable.