FABRICATION METHOD OF UNIFORM SUBMICRON DROPLETS AND POLYMERIC MONODIPERSE PARTICLES USING MICROFLUIDIC FLOW-FOCUSING DEVICES WITH THREE-DIMENSIONAL TOPOGRAPHY

摘要

PURPOSE: A method for stably manufacturing uniform nanometer-sized droplets and mono-dispersed particles using a three-dimensional microfluidic flow-focusing channel structure is provided to uniformly maintain the droplets and to freely control the size and the composition of the droplet. CONSTITUTION: A three-dimensional microfluidic flow-focusing channel structure has a water dispersed phase channel comprising an inlet and a guide tube. The channel is connected to an orifice. An oil continuous phase channel comprises an inlet and guide tubes at both sides of the inlet, and is connected to the orifice. A water-oil emulsion is generated in the orifice, passes through a downstream channel, and is discharged through an outlet. The heights of the water dispersed phase channel and the orifice are relatively below the heights of the oil continuous phase channel and the downstream channel. [Reference numerals] (AA) Continuous (oil) phase inlet; (BB) Dispersed (wool) phase inlet; (CC) Outlet; (DD) Countercurrent flow; (EE) Top view; (FF,LL) Continuous phase channel; (GG,NN) Downstream channel; (HH,KK) Dispersed phase channel; (II,MM) Orifice; (JJ) Side view