TARGETING VECTOR-PHOSPHOLIPID CONJUGATES

摘要

PROBLEM TO BE SOLVED: To provide methods of preparing targeting vector-phospholipid conjugates as targeting ultrasound contrast agents, which are useful in therapeutic and diagnostic compositions.SOLUTION: Peptide vectors may be conjugated to phospholipids. Peptide-phospholipid conjugates are included in ultrasound contrast agent compositions. Target peptide-phospholipid conjugates exhibit high KDR (kinase domain region) binding affinity and thus are useful in imaging angiogenesis processes and in the evaluation and treatment of angiogenic processes associated with neoplastic conditions.