| 摘要 |
Abstract This invention relates to protein separation and purification methods for both alpha-l antitrypsin (AAT, also known as alpha-i proteinase inhibitor, API, and A]-PI) and Apolipoprotein A-I (ApoA-1) from, for example, a fraction of human blood plasma. In certain embodiments, the invention provides methods for separating AAT from ApoA-1 at the initial stage of purification, so that the same starting material can be used as a source for both proteins. The methods further pertain to providing compositions of AAT and of ApoA-I suitable for pharmaceutical use and are suitable for large-scale purification. |
