| 摘要 |
<p>PURPOSE: A hydrogel is provided to use as a sealant, a tissue adhesive, a conglutination inhibitor and a drug delivery carrier etc by having the hydrogel in which a gelation time is short, a biocompatibility and a biodegradation property are shown, an adhesive force and a fracture strength are excellent. CONSTITUTION:γ-polyglutamic acid derivative is indicated as below chemical formula 1; and a total value of l, n and m are a whole number of 390-15,500; a ratio of l, n and m are l : m : n = 0-0.5 : 0.2-0.5 : 0.2-0.8; L is a linker, M is H, alkali metal or alkaline earth metal respectively, R is CH2, b is 0 or 1, C is the whole number of 1-5. The linker is -HN - (R) a-O-; R is the CH2, and a is the whole number of 1-5 in the linker. Moreover, hydrogel comprisesγ-polyglutamic acid derivative and a cross-linked unit in which polyethylene glycol polymer which has multiple nucleophilic functional groups is cross-linked.</p> |
