SCREENING METHODS OF APOPTOTIC INDUCER AGENTS USING ROR

摘要

PURPOSE: A method for screening cell apoptosis inducing materials using ROR alpha is provided to effectively screen leading compounds of novel drugs, which induce apoptosis, to improve hit ratio in preclinical and clinical tests, and to reduce cost and time for developing a novel drug. CONSTITUTION: A method for screening cell apoptosis inducing materials comprises the steps of: contacting test materials with cells containing ROR alpha gene or protein; and identifying the increase of ROR alpha protein in the cells. The method additionally comprises the step of measuring the activation of p53 transcript in the cells.