发明名称 |
PHOSPHONATE ESTER DERIVATIVES AND METHODS OF SYNTHESIS THEREOF |
摘要 |
The disclosure describes methods of synthesis of phosphonate ester derivatives. Preferred methods according to the disclosure allow for large-scale preparation of phosphonate ester compounds having high purity. In some embodiments, preferred methods according to the disclosure also allow for the preparation of phosphonate ester derivatives without the use of chromatographic purification methods and in better yield than previously used methods for preparing such compounds. Also disclosed are morphic forms of phosphonate ester derivatives. |
申请公布号 |
EP2611818(A2) |
申请公布日期 |
2013.07.10 |
申请号 |
EP20110822622 |
申请日期 |
2011.08.31 |
申请人 |
CHIMERIX, INC. |
发明人 |
WARE, ROY, W.;ALMOND, MERRICK, R.;LAMPERT, BERNHARD, M. |
分类号 |
C07F9/38;A61K31/675;A61K47/48;A61P31/12;C07F9/40;C07F9/6512;C07F9/6571 |
主分类号 |
C07F9/38 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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