发明名称 |
MULTIVALENT CLOSTRIDIAL TOXINS |
摘要 |
<p>The present invention is directed to multivalent Clostridial neurotoxin derivatives having more than one binding domain directed to a cell surface feature of a target cell. Such modified neurotoxins are useful as therapeutic compositions to prevent exocytosis and secretion by the target cell. Conditions in which such compositions may be useful include, without limitation, disorders of the sensory or motor nervous system, acute or chronic pain, cancer, pancreatitis, hyperhydrosis, glandular disorders, viral infections, cystic fibrosis and the like. The invention is also directed to methods of using and administering such a composition, and methods of treating a given condition using such a composition.</p> |
申请公布号 |
EP1999142(B1) |
申请公布日期 |
2013.07.10 |
申请号 |
EP20070758409 |
申请日期 |
2007.03.13 |
申请人 |
ALLERGAN, INC. |
发明人 |
STEWARD, LANCE, E.;FERNANDEZ-SALAS, ESTER;FRANCIS, JOSEPH;LI, SHENGWEN;GILMORE, MARCELLA, A.;AOKI, KEI, ROGER |
分类号 |
C07K14/33;A61K38/48;C12N15/62 |
主分类号 |
C07K14/33 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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