| 摘要 |
FIELD: biotechnology.SUBSTANCE: invention relates to determining the activity of pyruvate dehydrogenase complex (PDH complex) byC-MP detection (magnetic resonance detection based on the isotopeC). The essence of the method consists in that the change in activity of PDH complex in the subject to be examined byC-MR detection (magnetic resonance detection based on the isotopeC) is determined using the medium of visualisation comprising hyperpolarisedC-pyruvate, and when detecting a signal ofC-bicarbonate or the signal ofC-bicarbonate and the signal ofC-pyruvate where the said hyperpolarisedC-pyruvate is selected from the group consisting of hyperpolarizedC-pyruvate,C-pyruvate,C-pyruvate orC-pyruvate or any of their combination, the activity of PDH complex is determined.EFFECT: use of the claimed method enables to determine reliably changes in activity of PDH complex in the subject to be examined.11 cl, 7 dwg, 5 ex |
