Aminothiazolidine and aminotetrahydrothiazepine derivatives as BACE 1 inhibitors

摘要

A composition having BACE 1 inhibitory activity containing a compound represented by the general formula (I):
wherein ring A is an optionally substituted carbocyclic group or an optionally substituted heterocyclic group;
E is lower alkylene;
X is S, O, or NR 1 ;
R 1 is a hydrogen atom or lower alkyl;
R 2a , R 2b , R 3a , R 3b , R 4a and R 4b is each independently a hydrogen atom, halogen, or hydroxy etc.;
n and m are each independently an integer of 0 to 3;
n+m is an integer of 0 to 3;
R 5 is a hydrogen atom or substituted lower alkyl;
its pharmaceutically acceptable salt, or a solvate thereof.