发明名称 |
IDENTIFICATION AND SELECTION OF STEM CELLS BEING COMMITTED TO DIFFERENTIATE TO A SPECIFIC TYPE FOR OBTAINING A HOMOGENEOUS POPULATION OF STEM CELLS |
摘要 |
<p>The stem cell (1) includes a cellular DNA (2) comprising a plurality of sequences coding different genes and promoters allowing DNA-protein-interactions, at least one protein molecule (3) generated by means of a specific stimulus (12) and at least one DNA-molecule (6) artificially introduced into the stem cell (1). The artificially introduced DNA-molecule (6) comprises at least one binding site sequence (30) being apt to interact with the protein molecule (3), at least one DNA-sequence (40) coding an indicator molecule (5) and at least one minimal promoter sequence (50), allowing the gene expression of said indicator molecule (5), whereby the stem cell further includes at least one indicator molecule (5) having properties allowing its identification and is produced by synthesis of the DNA-sequence (40) coding an indicator molecule (5) of the artificially introduced DNA-molecule (6).</p> |
申请公布号 |
EP1907531(B1) |
申请公布日期 |
2013.07.10 |
申请号 |
EP20060761276 |
申请日期 |
2006.08.11 |
申请人 |
AO-FORSCHUNGSINSTITUT DAVOS |
发明人 |
ALINI, MAURO;STODDART, MARTIN |
分类号 |
C12N5/077;C12N5/0775 |
主分类号 |
C12N5/077 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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