| 摘要 |
<p>The invention relates to derivatizing agents for biogenic amines in order to produce aminated haptenes which provide antibodies after coupling to a support, said antibodies being capable of binding the aminated haptene with a higher affinity. The invention relates to various competing immunoassays using said antibodies for determining biogenic amines in bodily fluids. The derivatizing agent contains groups which can potentially form Pi adducts with amino acids of the CDR of the antibody. The groups are in close proximity to the reactive group that can react with the amine radical of the biogenic amine. Preferred examples of the derivatizing agent are compounds of formulae (III) and (IV).</p> |
