| 发明名称 |
BACE INHIBITORS FOR USE IN THE TREATMENT OF DIABETES |
| 摘要 |
<p>The present invention relates to N-1-Benzyl-2-hydroxy-3-(hetero)arylamino-propyl)-isophthalamides of formula I having BACE2 inhibitory activity and their use as therapeutically active substances, their manufacture and pharmaceutical compositions. The active compounds of the present invention are useful in the therapeutic and/or prophylactic treatment of e.g. type 2 diabetes.</p> |
| 申请公布号 |
EP2611441(A1) |
申请公布日期 |
2013.07.10 |
| 申请号 |
EP20110748683 |
申请日期 |
2011.08.29 |
| 申请人 |
F.HOFFMANN-LA ROCHE AG |
发明人 |
MAUSER, HARALD;NETTEKOVEN, MATTHIAS;SCHMITT, SEBASTIEN |
| 分类号 |
A61K31/381;A61K31/40;A61K31/4155;A61K31/422;A61K31/4245;A61K31/427;A61K31/4418;A61P3/10;C07D207/00;C07D207/10;C07D213/16;C07D231/14;C07D233/26;C07D263/34;C07D275/02 |
主分类号 |
A61K31/381 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
|
| 地址 |
|
