Photodynamic Therapy and Diagnosis

摘要

The present invention relates to Chlorin e4 sodium, preferably with chlorine e4 and sodium in a ratio of 1:2: A process for its preparation preferably comprises reaction of chlorine e4 in methanol with aqueous sodium hydroxide, optionally with addition of an amine base such as thiamine pyrophosphate, followed by lyophilisation. Chlorin e4 sodium may be useful in photodynamic therapy, cytoluminescent therapy and photodynamic diagnosis, for example for treating or detecting a tumour. A pharmaceutical composition comprising chlorin e4 sodium and the use of chlorin e4 sodium in the manufacture of a phototherapeutic or photodiagnostic agent are also detailed.