DERIVATIVES OF (3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-17-((R)-4-(1,2,4-OXADIAZOLE -5-YL)BUTANE-2-YL)-10,13-DIMETHYLHEXADECAHYDRO-1H-CYCLOPENTA[A]PHENANTHRENE -3,7,12-TRIOL

摘要

The invention relates to organic chemistry, in particular to derivatives of (3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-17-((R)-4-(1,2,4-oxadiazole -5-yl)butane-2-yl)-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthrene -3,7,12-triol of general formula:,wherein R is 5- or 6-membered heterocycle attached through carbon atom and comprising one heteroatom of series nitrogen, oxygen or sulphur, or phenol radical, that are optionally substituted by one or more substituents of series halogen, or C-C-alkyl, or -CFor -OR, or benzoxy, or substituent of formula,wherein Ris hedrogen or C-C-alkyl,Ris C-C-alkyl,Ris C-C-alkyl.