发明名称 |
HUMAN IMMUNODEFICIENCY VIRUS (HIV-1) HIGHLY CONSERVED AND LOW VARIANT SEQUENCES AS TARGETS FOR VACCINE AND DIAGNOSTIC APPLICATIONS |
摘要 |
We identified regions of the HIV-1 proteome with high conservation, and low variant incidence. Such highly conserved sequences have direct relevance to the development of new-generation vaccines and diagnostic applications. The immune relevance of these sequences was assessed by their correlation to previously reported human T-cell epitopes and to recently identified human HIV-1 T-cell epitopes (identified using HLA transgenic mice). We identified (a) sequences specific to HIV-1 with no shared identity to other viruses and organisms, and (b) sequences that are specific to primate lentivirus group, with multiclade HIV-1 conservation.
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申请公布号 |
EP2521733(A4) |
申请公布日期 |
2013.07.10 |
申请号 |
EP20110728565 |
申请日期 |
2011.01.04 |
申请人 |
AUGUST, THOMAS;NATIONAL UNIVERSITY OF SINGAPORE;SIMON, GREGORY |
发明人 |
AUGUST, J. THOMAS;SIMON, GREGORY GEORGE;TAN, TIN WEE;KHAN, ASIF MOHAMMAD;YONGLI, HU |
分类号 |
C07K14/16;A61K39/21;A61P31/18;C12N15/49;C12N15/63;C12Q1/70 |
主分类号 |
C07K14/16 |
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