发明名称 |
METHOD OF GENERATING SINGLE VL DOMAIN ANTIBODIES IN TRANSGENIC ANIMALS |
摘要 |
The present invention describes a single variable domain comprising a human VL domain segment, a DH domain segment, and a human JL domain segment. Provided is also a polynucleotide encoding a respective single variable domain. Further provided are a non-human mammalian cell with a genome that encodes the single variable domain and a hybridoma cell derived from such a non-human mammal. |
申请公布号 |
EP2288623(B1) |
申请公布日期 |
2013.07.10 |
申请号 |
EP20090751700 |
申请日期 |
2009.05.22 |
申请人 |
ABLEXIS, LLC |
发明人 |
SHIZUYA, HIROAKI;GREEN, LARRY |
分类号 |
C07K16/46;A01K67/027;A61K39/395;C07K16/18;C12N5/10;C12N15/13 |
主分类号 |
C07K16/46 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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