| 摘要 |
FIELD: chemistry.SUBSTANCE: invention provides to a high degree a safe pharmaceutical drug which is effective for diseases caused by MMP-2 and/or MMP-9. The pharmaceutical drug contains, as an active ingredient, at least one member selected from a group which consists of thiazole derivatives of formula(1): where Ris a phenyl group which can have 1-3 lower alkoxy groups as substitutes in the phenyl ring, and Ris a pyridyl group which can have 1-3 carboxyl groups as substitutes in the pyridine ring, or salts thereof.EFFECT: high activity and use when treating diseases such as fibrosis and pulmonary emphysema.4 cl, 4 ex, 2 tbl |
