发明名称 Compounds which have activity at M1 receptor and their uses in medicine
摘要 Compounds of formula (I) and salts and solvates are provided: wherein R4 is fluoro, R5 is selected from hydrogen, halogen, cyano, C1-6alkyl, C1-6alkyl substituted with one or more fluorine atoms, C1-6alkoxy, and C1-6alkoxy substituted with one or more fluorine atoms; and R6 is selected from halogen, cyano, C1-6alkyl, C1-6alkyl substituted with one or more fluorine atoms, C3-6cycloalkyl, C3-6cycloalkyl substituted with one or more fluorine atoms, C1-6alkoxy and C1-6alkoxy substituted with one or more fluorine atoms, and Q is hydrogen or C1-6alkyl. The compounds are expected to be useful for therapy, for example in the treatment of psychotic disorders and cognitive impairment.
申请公布号 US8481566(B2) 申请公布日期 2013.07.09
申请号 US20070852455 申请日期 2007.09.10
申请人 BUDZIK BRIAN;COOPER DAVID GWYN;FORBES IAN THOMSON;GARZYA VINCENZO;JIN JIAN;SHI DONGCHUAN;WALKER GRAHAM;GLAXO GROUP LIMITED 发明人 BUDZIK BRIAN;COOPER DAVID GWYN;FORBES IAN THOMSON;GARZYA VINCENZO;JIN JIAN;SHI DONGCHUAN;WALKER GRAHAM
分类号 A61K31/445;C07D401/04 主分类号 A61K31/445
代理机构 代理人
主权项
地址