发明名称 Platinum-N-heterocyclic carbene derivatives, preparation thereof and therapeutic use thereof
摘要 The invention relates to the platinum N-heterocycle derivatives of general formula (I) in which-R1 and/or R2 are, independently of one another, an aryl or aralkyl group, each optionally substituted, a linear or branched C1-C6 alkyl group, a monocyclic C3-C7 cycloalkyl group or a linear or branched C2-C6 alkenyl group, or else R' is a hydrogen atom and R is a group selected from the following groups: cycloalkyl or heterocycloalkyl, which is monocyclic or bicyclic and has from 3 to 8 carbon atoms, or benzyl, which is optionally substituted, or else R and R' form, together with NH, a C3-C8 monocyclic or bicyclic heterocycloalkyl, V is a nitrogen atom or a C-R4 radical, R3 and/or R4 are hydrogen or a phenyl group or R3 and R4 may also together form a C3-C6 alkylene radical or a C3-C6 heteroalkylene radical with one or more nitrogenous heteroatoms, it being possible for the carbon atoms of the heteroalkylene radical to be modified in the form of a carbonyl radical, and X is iodine, bromine, chlorine or a nitrato (-ONO2) group.
申请公布号 US8481522(B2) 申请公布日期 2013.07.09
申请号 US20100874815 申请日期 2010.09.02
申请人 MAILLIET PATRICK;MARINETTI ANGELA;SKANDER MYRIEM;SANOFI;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE 发明人 MAILLIET PATRICK;MARINETTI ANGELA;SKANDER MYRIEM
分类号 A61K31/555;C07F15/00 主分类号 A61K31/555
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