METHOD FOR THE PREPARATION OF MICROSPHERES OF BIODEGRADABLE POLYLACTIC ACID DERIVATIVE WITH NO USE OF ORGANIC SOLVENTS

摘要

PURPOSE: A microsphere manufactured using a biodegradable polylactic acid derivative microsphere manufacturing method not using the organic solvent is provided to be able to use a needle of thinner thickness by changing the microsphere shape to a constant sphere feasibly and effectively on constant emission and initial burst suppression. CONSTITUTION: A polymeric microsphere manufacturing method comprises a) a step of manufacturing polymer solvent containing solution by mixing solution to polylactic acid derivative aqueous solution of below chemical equation 1 with less than 7000 dalton average molecular weight, b) a step of precipitating the drug containing polymer solution by adding to the aqueous solution of polyvalent metal salt, c) a step of manufacturing micro particle in size of 1-150 micrometers by crushing after drying the precipitated drug containing polymer, d) a step of stirring after suspending the micro particle to polyvinyl alcohol aqueous solution, and e) a step of separating the microsphere produced after coolinig the obtained mixture.