发明名称 Solid forms of a chemokine receptor antagonist and methods of use thereof
摘要 The citrate salt of (S)-4-(4-Chloro-phenyl)-1-{3-[7-(1-hydroxy-1-methyl-ethyl)-11H-10-oxa-1-aza-dibenzo[a,d]cyclohepten-5-ylidene]-propyl}-3,3-dimethyl-piperidin-4-ol, which may be used in pharmaceutical applications, is disclosed. The crystalline Citrate Salt, including particular single crystal forms and combinations of the single crystalline forms, are also discussed. Mixtures for forming the crystalline salts are discussed. As well, methods of producing the Citrate Salt, and crystalline forms thereof, and using such Citrate Salt, and crystalline forms thereof, in treating diseases associated with aberrant leukocyte recruitment, activation, or recruitment and activation are also discussed.
申请公布号 US8481737(B2) 申请公布日期 2013.07.09
申请号 US201113116130 申请日期 2011.05.26
申请人 NEVES CAROLE;CHEVALIER AURELIA;BILLOT PASCAL;MILLENNIUM PHARMACEUTICALS, INC. 发明人 NEVES CAROLE;CHEVALIER AURELIA;BILLOT PASCAL
分类号 C07D491/044;A61K31/4353 主分类号 C07D491/044
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