COMPOSITION COMPRISING GAMMA-SECRETASE INHIBITOR FOR PREVENTING OR TREATING RHEUMATOID ARTHRITIS

摘要

PURPOSE: A gamma-secretase inhibitor is provided to regulate immunocyte activation, differentiation, and proliferation, to suppress generation of notch intracellular domain (NICD) which plays a role in notch signal transduction, and to be used as a pharmaceutical product and health food for preventing or treating rheumatic arthritis. CONSTITUTION: A pharmaceutical composition for preventing or treating rheumatic arthrisi contains RO4929097 (CAS No. 847925-91-1) of chemical formula 1 as an active ingredient. RO4929097 suppresses the generation of NICD. A food composition for preventing rheumatic arthritis contains RO4929097 as an active ingredient. RO4929097 is C_22H_20F_5N_3O_3. The molecular weight of RO4929097 is 469.4.