发明名称 |
EQUIVALENT TISSULAIRE NON RETRACTE, EQUIVALENT DE PEAU COMPORTANT UN TEL EQUIVALENT TISSULAIRE NON RETRACTE |
摘要 |
<p>The invention relates to a method for producing an unshrunken tissue equivalent. Said method is comprising in that: a mixture is produced that contains at least one element of an extracellular matrix; at least one pluridimensional medium is soaked with said mixture; from the components of the mixture, a lattice comprising at least one element of an extracellular matrix is produced, at least at the medium; at least part of the components of said mixture is attached to the structure of the medium; the shrinking of at least the lattice is prevented and at least said lattice is tensioned on said medium; fibroblasts are integrated into the lattice and at least one cell culture of said fibroblasts is carried out, at least in the lattice. The invention also relates to a method for producing a skin equivalent that comprises at least one dermal equivalent formed by an unshrunken tissue equivalent and at least one epidermal equivalent.</p> |
申请公布号 |
FR2947562(B1) |
申请公布日期 |
2013.07.05 |
申请号 |
FR20090058919 |
申请日期 |
2009.12.14 |
申请人 |
UNIVERSITE DE FRANCHE-COMTE;CENTRE HOSPITALIER UNIVERSITAIRE DE BESANCON |
发明人 |
HUMBERT PHILIPPE;BINDA DELPHINE;VIENNET-STEINER CELINE;ROBIN SOPHIE;ROLIN GWENAEL;TAUZIN HELENE;PAZART LIONEL |
分类号 |
C12N5/071;A61F2/10;A61L27/38;C12N5/02;C12Q1/02 |
主分类号 |
C12N5/071 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|