INSULSIN DERIVATIVE WITH ANTIHYPERGLYCEMIC ACTIVITY AND METHOD FOR THE PRODUCTION THEREOF

摘要

The invention relates to pharmaceutics and medicine and, more specifically, to compositions of a biologically active substance, in particular supramolecular assemblies of acylated insulin oligopeptides, for oral administration in the treatment of diabetes mellitus and complications thereof. The proposed system makes it possible, using a single oral dose, to maintain the level of glucose in the blood at a physiological level for 24 hours (super effect), and the ingredients of the system acquire resistance to enzymatic action, have small dimensions and can be easily absorbed from the intestines. Essence of the invention: The principle active agents are in the form of a supramolecular composition, namely an assembly consisting of acylated oligopeptide products of the enzymatic hydrolysis of insulin. The composition can be produced industrially in sufficient amounts on account of the availability of all of the ingredients of the composition.