发明名称 |
METHOD AND COMPOSITIONS FOR DETECTING EPIDERMAL GROWTH FACTOR RECEPTOR VARIANT FORMS IN CANCER CELLS |
摘要 |
Method and compositions for screening for the presence of Epidermal Growth Factor Receptor variant 3 (EGFR(v3)) in a sample are described. The method comprises obtaining a sample containing a plurality of cells; hybridizing a set of chromosomal probes to the sample, wherein the set comprises an EGFR(v3)-probe and a probe to chromosome 7 different from an EGFR(v3)-probe; and visualizing the hybridization pattern of the set of chromosomal probes in the plurality of cells of the sample, wherein the presence of at least one copy of chromosome 7 lacking a hybridization signal of the EGFR(v3)-probe in at least one cell is indicative of the presence of the EGFR(v3) in the sample. The method and compositions are suitable for diagnosing the therapeutic outcome for treating a patient having a cancer with an anti-EGFR therapeutic agent and for screening a sample for a predisposition for forming an EGFR-associated cancer.
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申请公布号 |
US2013171641(A1) |
申请公布日期 |
2013.07.04 |
申请号 |
US201213728912 |
申请日期 |
2012.12.27 |
申请人 |
ABBOTT MOLECULAR INC.;ABBOTT MOLECULAR INC. |
发明人 |
JEWELL SUSAN S.;RUSSELL JOHN C.;MORRISON LARRY E. |
分类号 |
C12Q1/68 |
主分类号 |
C12Q1/68 |
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