| 摘要 |
PROBLEM TO BE SOLVED: To provide a method for producing 3-hydroxypropionic acid and other products.SOLUTION: This invention relates to metabolically engineered microorganism strains, such as bacterial strains, in which there is an increased utilization of malonyl-CoA for production of a chemical product, which includes 3- hydroxypropionic acid. In certain embodiments, the cell culture comprises an inhibitor of fatty acid synthase or the microorganism is genetically modified for reduced enzymatic activity in the organism's fatty acid synthase pathway. For example, the inhibitor of the fatty acid synthase may be selected from the group consisting of thiolactomycin, triclosan, cerulenin, thienodiazaborine, isoniazid, and analogs thereof. |
