| 摘要 |
PROBLEM TO BE SOLVED: To provide connection type low-flow separation techniques.SOLUTION: The present disclosure provides, among other things, approaches for connecting low flow separation techniques, such as capillary electrophoresis and nano HPLC to mass spectrometry via electrospray ionization. More particularly, the present disclosure concerns capillary columns having a porous segment or porous tip useful for connecting low flow separation techniques as well as methods and systems using such capillary columns. The design of the porous tip of the present disclosure has several advantages over previous designs. First, production may be automated and the mass may be produced in a reproducible manner. Another advantage is that several capillary outlets may be etched at about the same time in about 30 min (for 150-μm-o.d. and 20-μm-i.d. capillaries). |
