发明名称 |
OLIGONUCLEOTIDE, AND THERAPEUTIC AGENT FOR DYSLIPIDEMIA CONTAINING OLIGONUCLEOTIDE AS ACTIVE INGREDIENT |
摘要 |
An object of the present invention is to provide an oligonucleotide useful as a therapeutic agent for dyslipidemia that has excellent binding affinity to the PCSK9 gene as well as stability and safety. The oligonucleotide of the present invention contains a sugar-modified nucleoside, the sugar-modified nucleoside has a bridging structure between 4'-position and 2'-position, and the oligonucleotide can bind to the human PCSK9 gene. Also, the present invention provides a therapeutic agent for dyslipidemia containing the oligonucleotide as an active ingredient, and the therapeutic agent preferably contains a bioabsorbable material as a carrier. The bioabsorbable material is preferably atelocollagen or peptide gel.
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申请公布号 |
US2013172402(A1) |
申请公布日期 |
2013.07.04 |
申请号 |
US201113819722 |
申请日期 |
2011.08.31 |
申请人 |
OBIKA SATOSHI;IMANISHI TAKESHI;YAMAMOTO TSUYOSHI;NARUKAWA KEISUKE;SHIBA MARIKO;YAMAOKA TETSUJI;TORIGOE HIDETAKA;YAMASHITA ATSUSHI;TACHIBANA YOICHI;KAKINOKI SACHIRO;SASAKI KIYOMI;OSAKA UNIVERSITY;TOKYO UNIVERSITY OF SCIENCE EDUCATIONAL FOUNDATION ADMINISTRATIVE ORGANIZATION;NATIONAL CEREBRAL AND CARDIOVASCULAR CENTER |
发明人 |
OBIKA SATOSHI;IMANISHI TAKESHI;YAMAMOTO TSUYOSHI;NARUKAWA KEISUKE;SHIBA MARIKO;YAMAOKA TETSUJI;TORIGOE HIDETAKA;YAMASHITA ATSUSHI;TACHIBANA YOICHI;KAKINOKI SACHIRO;SASAKI KIYOMI |
分类号 |
C12N15/113 |
主分类号 |
C12N15/113 |
代理机构 |
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代理人 |
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地址 |
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