USE OF ESTROGEN DERIVATIVES FOR THE MANUFACTURE OF PHARMACEUTICAL PRODUCTS USEFUL FOR THE PROPHYLAXIS AND/OR TREATMENT OF PSYCHIATRIC DISEASES

摘要

The object of the invention is the use of the derivatives of 17-alpha-estradiol of formula (I) where R means . ethyl, higher alkyl, cycloalkyl, aryl and heterocycle as well as hydroxyl, alkyl groups containing amino and carboxy groups; or . CO-O-R', where R' means alkyl, cycloalkyl, aryl and heterocycle; or . CO-(R")-0-Q, where R" means alkyl, Q means alkyl, cycloalkyl, aryl and heterocycle, for the treatment and/or prevention of psychiatric diseases. According to the invention 17-alpha-estradiol derivatives can be used primarily as an antidepressant, more preferably fast- acting antidepressant. According to the invention derivatives of 17-alpha-estradiol of formula (I) can be used to treat and/or prevent post-partum depression, peri-menopausal depression, anxiety, schizophrenia, memory disturbance associated with depression, bipolar depression, Alzheimer-disease or post-traumatic stress disease.