Short RNA antagonist compounds for the modulation of target mRNA
摘要
The invention provides LNA gapmer oligomers of between 10 - 20 nucleobases in length, which have a total of 1 - 3 phosphodiester internucleoside linkages. Such oligomers have been found to have superior bioavailability and have also been found to selectively accumulate in kidney cells.
申请公布号
EP2149605(B1)
申请公布日期
2013.07.03
申请号
EP20090169826
申请日期
2008.03.19
申请人
SANTARIS PHARMA A/S
发明人
HANSEN, JENS BO;ORUM, HENRIK;HANSEN, HENRIK;STRAARUP, ELLEN MARIE;NIELSEN, NIELS FISKER;HEDTJAERN, MAJ