| 发明名称 |
GENOME EDITING OF A ROSA LOCUS USING ZINC-FINGER NUCLEASES |
| 摘要 |
Disclosed herein are methods and compositions for genome editing of a Rosa locus, using fusion proteins comprising a DNA binding domain and a cleavage domain or cleavage half-domain. Polynucleotides encoding said fusion proteins are also provided, as are cells comprising said polynucleotides and fusion proteins. |
| 申请公布号 |
KR20130073879(A) |
申请公布日期 |
2013.07.03 |
| 申请号 |
KR20127027879 |
申请日期 |
2011.04.25 |
| 申请人 |
SANGAMO BIOSCIENCES, INC.;SIGMA ALDRICH CO. LLC |
发明人 |
CUI XIAOXIA;DAVIS GREGORY;GREGORY PHILIP D.;HOLMES MICHAEL C.;WEINSTEIN EDWARD J. |
| 分类号 |
C07K19/00;A01K67/027;C12N5/10;C12N15/62 |
主分类号 |
C07K19/00 |
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