发明名称 |
SWITCHING FLUORESCENT NANOPARTICLE PROBE AND FLUORESCENT PARTICLE IMAGING METHOD USING SAME |
摘要 |
The present invention provides a novel fluorescent nanoparticle imaging probe having a switching function (a function to quench a fluorescent dye during nanoparticle preparation, and emit fluorescence during imaging). A switching fluorescent nanoparticle probe comprising: a molecular assembly composed of an amphiphilic block polymer having a hydrophilic block chain and a hydrophobic block chain; and a fluorescent dye encapsulated in the molecular assembly, wherein (a) the hydrophilic block chain comprises, as an essential hydrophilic structural unit, a unit selected from a sarcosine unit and an alkylene oxide unit, (b) the hydrophobic block chain comprises, as an essential hydrophobic structural unit, a unit selected from the group consisting of an amino acid unit and a hydroxylic acid unit, and (c) the fluorescent dye is a cyanine compound represented by the formula (I):
and two or more molecules of the fluorescent dye are encapsulated in the single molecular assembly. |
申请公布号 |
EP2609935(A1) |
申请公布日期 |
2013.07.03 |
申请号 |
EP20110819780 |
申请日期 |
2011.08.08 |
申请人 |
SHIMADZU CORPORATION;KYOTO UNIVERSITY |
发明人 |
HARA, ISAO;OZEKI, EIICHI;SAJI, HIDEO;KIMURA, SHUNSAKU;ONO, MASAHIRO;TEMMA, TAKASHI |
分类号 |
A61K49/00;A61K9/51;A61K47/34;A61K47/42 |
主分类号 |
A61K49/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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