发明名称 |
Methods relating to aromatase inhibitor pharmacogenetics |
摘要 |
Methods for aiding in determining therapeutic efficacy of an aromatase inhibitor in a subject are provided according to embodiments of the present invention which include detecting expression and/or function of at least one UDP-glucuronosyltransferase having activity to modify at least one aromatase inhibitor and/or metabolite of the aromatase inhibitor by glucuronidation, wherein detection of expression and/or function of the UDP-glucuronosyltransferase is correlated with therapeutic efficacy of the aromatase inhibitor in the subject. Detection of UDP-glucuronosyltransferase expression and/or function includes detection of a UDP-glucuronosyltransferase gene deletion polymorphism in the subject.
|
申请公布号 |
US8476023(B2) |
申请公布日期 |
2013.07.02 |
申请号 |
US20100852957 |
申请日期 |
2010.08.09 |
申请人 |
LAZARUS PHILIP;SUN DONGXIAO;THE PENN STATE RESEARCH FOUNDATION |
发明人 |
LAZARUS PHILIP;SUN DONGXIAO |
分类号 |
C12Q1/68;C12N15/52;C12N15/54 |
主分类号 |
C12Q1/68 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|