Anchored multi-phasic osteochondral construct

摘要

Disclosed are osteochondral constructs that can be utilized to encourage both bone and articular cartilage tissue repair in synovial joints. Disclosed constructs are composites including a hydrogel portion for implant in a cartilage defect site and an adjacent portion for implant in a bone defect site. The portion to be implanted in a bone defect site can include a polymeric/ceramic composite material. Disclosed constructs also include a polymeric anchor that can secure the construct at the desired site. Disclosed constructs can also include capillary channeled fibers within the bone portion of the construct that can provide improved nutrient flow to and waste flow from cells growing and developing on and in the construct.