| 摘要 |
The present invention is directed to a method for the prophylactic and therapeutic treatment of age-related macular degeneration as well as methods for the prophylactic and therapeutic treatment of exudative and atrophic complications of age-related macular degeneration. The methods involve the administration of an inhibitor of the protein tyrosine kinase pathway to an animal, such as a mammal, in particular a human, in an amount sufficient to treat the animal for age-related macular degeneration or an exudative or atrophic complication thereof, respectively, prophylactically or therapeutically. The present invention further provides a method for the prophylactic and therapeutic treatment of degeneration of the retina, a method for the prophylactic and therapeutic treatment of degeneration of the choroid, and a method for the prophylactic and therapeutic treatment of thickening of Bruch's membrane. These methods involve the administration of an inhibitor of the protein tyrosine kinase pathway to an animal, such as a mammal, in particular a human, in an amount sufficient to treat the macula, retina, choroid or Bruch's membrane, respectively, prophylactically or therapeutically. The inhibitor of the protein tyrosine kinase pathway is preferably genistein or an analogue or prodrug thereof or a pharmaceutically acceptable salt of any of the foregoing.
|
