发明名称 |
N-(3-(2-amino-6,6-difluoro-4,4A,5,6,7,7A-hexahydro-cyclopenta[E][1,3]oxazin-4-yl)-phenylamides as BACE1 inhibitors |
摘要 |
The present invention provides N-(3-(2-amino-6,6-difluoro-4,4a,5,6,7,7a-hexahydro-cyclopenta[e][1,3]oxazin-4-yl)-phenyl)-amides of formula I having BACE1 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are useful in the therapeutic and/or prophylactic treatment of e.g. Alzheimer's disease.
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申请公布号 |
US8476264(B2) |
申请公布日期 |
2013.07.02 |
申请号 |
US201213609304 |
申请日期 |
2012.09.11 |
申请人 |
HILPERT HANS;PINARD EMMANUEL;WOLTERING THOMAS;HOFFMANN-LA ROCHE INC. |
发明人 |
HILPERT HANS;PINARD EMMANUEL;WOLTERING THOMAS |
分类号 |
C07D265/08;A61K31/5355;C07D413/12;C07D417/12 |
主分类号 |
C07D265/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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