发明名称 |
Insulinotropic complex using an immunoglobulin fragment |
摘要 |
The present invention relates to an insulinotropic peptide conjugate having improved in-vivo duration of efficacy and stability, comprising an insulinotropic peptide, a non-peptide polymer and an immunoglobulin Fc region, which are covalently linked to each other, and a use of the same. The insulinotropic peptide conjugate of the present invention has the in-vivo activity which is maintained relatively high, and has remarkably increased blood half-life, and thus it can be desirably employed in the development of long acting formulations of various peptide drugs.
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申请公布号 |
US8476230(B2) |
申请公布日期 |
2013.07.02 |
申请号 |
US20080523050 |
申请日期 |
2008.01.04 |
申请人 |
SONG DAE HAE;LIM CHANG KI;SONG TAE HUN;KIM YOUNG HOON;KWON SE CHANG;LEE GWAN SUN;JUNG SUNG YOUB;CHOI IN YOUNG;HANMI SCIENCE CO., LTD |
发明人 |
SONG DAE HAE;LIM CHANG KI;SONG TAE HUN;KIM YOUNG HOON;KWON SE CHANG;LEE GWAN SUN;JUNG SUNG YOUB;CHOI IN YOUNG |
分类号 |
A61K38/00;A61K39/395;A61P5/50 |
主分类号 |
A61K38/00 |
代理机构 |
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