Compositions and methods for the delivery of nitric oxide

摘要

NZ 594456 Disclosed is an isolated H-NOX protein comprising at least one distal pocket mutation wherein the mutation is a replacement of a residue that corresponds to position 74 of Thermoanaerobacter tengcongensis H-NOX by any other amino acid, wherein the mutation alters the NO dissociation constant or NO reactivity compared to that of a corresponding wild-type H-NOX protein.