Compositions and methods for the delivery of oxygen

摘要

NZ 594457 Disclosed is an isolated H-NOX protein comprising at least one distal pocket mutation, wherein the mutation is a replacement of a residue that corresponds to L144 of T. tengcongensis H-NOX by any other amino acid, wherein the mutation alters the oxygen dissociation constant or NO reactivity compared to that of a corresponding wild-type H-NOX protein.