| 摘要 |
<P>PROBLEM TO BE SOLVED: To provide conjugates of synthetic TLR agonists. <P>SOLUTION: There are provided TLR agonists and conjugates thereof useful in vaccines and to prevent, inhibit or treat a variety of disorders including pathogen infection and asthma. There are provided conjugates of a synthetic TLR agonist linked via a stable covalent bond to a macromolecule and compositions having those conjugates, as well as methods of using the conjugates. The conjugates may include macromolecules directly linked to a synthetic TLR agonist, e.g., TLR7 or TLR9 agonists, or linked via a linker to the TLR agonist, for instance, linked via an amino group, a carboxy group or a succinamide group. <P>COPYRIGHT: (C)2013,JPO&INPIT |
