VARIANT FC-POLYPEPTIDES WITH ENHANCED BINDING TO THE NEONATAL FC RECEPTOR
摘要
Described herein are variant Fc-fragments that contain an insertion within or adjacent to a loop that bind to the neonatal Fc receptor (FcRn) with higher affinity and/or higher binding activity at pH 5-6 and approximately the same or lower affinity at a physiologic pH as compared to a control Fc-fragment, that is, little or no binding activity at a physiologic pH. Also described are variant Fc-polypeptides that comprise these variant Fc-fragments. Further described are methods of making and identifying such Fc-fragments and methods for making and using such Fc-polypeptides.
申请公布号
CA2859785(A1)
申请公布日期
2013.06.27
申请号
CA20122859785
申请日期
2012.12.17
申请人
AMGEN INC.
发明人
SUN, JEONGHOON;HAN, SEOG JOON;HARRIS, SUSIE M.;KETCHEM, RANDAL R.;LU, JI;MICHAELS, MARK L.;RETTER, MARC W.;TSAI, MEI-MEI