| 发明名称 |
4-[17BETA-METHOXY-17ALPHA-METHOXYMETHYL-3-OXOESTRA-4,9-DIEN-11-BETA-YL]BENZALDEHYDE (E)-OXIME (ASOPRISNIL) |
| 摘要 |
The present invention relates to a method for the reliable and reproducible preparation of 4-[17beta-methoxy-17alpha-methoxymethyl-3-oxoestra-4,9-dien-11beta-yl]benzaldehyde (E)-oxime (asoprisnil) on the pilot and manufacturing scale. Asoprisnil, which is prepared by this method, is distinguished by a very good physical stability and is therefore particularly suitable for the manufacture of solid pharmaceutical forms (tablets, coated tablets, etc.).
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| 申请公布号 |
US2013165421(A1) |
申请公布日期 |
2013.06.27 |
| 申请号 |
US201213690736 |
申请日期 |
2012.11.30 |
| 申请人 |
BAYER PHARMA AG;BAYER PHARMA AG |
发明人 |
GRAWE DETLEF;GLIESING SABINE;GERECKE HAGEN;HOESEL PETER;MUELLER UWE;MICHEL THOMAS;EILERS ROBERT;KNABE UWE;ERHART BERND;MOSEBACH MICHAEL;VOIGTLAENDER DAVID;TILSTAM ULF;JACKE JURGEN;BAHL KLAUS;BOHLMANN ULF;WEHMEIER DIETER;SANDER MICHAEL |
| 分类号 |
C07J75/00;C07J41/00 |
主分类号 |
C07J75/00 |
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