发明名称 |
METHOD OF PRODUCING LIPID NANOPARTICLES FOR DRUG DELIVERY |
摘要 |
<p>What is described is a method for preparing a liposome that efficiently encapsulates a negatively charged therapeutic polymer, e.g., siRNA. The process involves preparing a lipid mixture comprising a cationic lipid in a water miscible organic solvent such as ethanol, and injecting this solution to the polymer dissolved in water to a final concentration of 35% ethanol in water to produce nanoparticles having a mean size of 50 to 150 nm and a final charge ratio of drug:lipid is 1 :2.5.</p> |
申请公布号 |
CA2853689(A1) |
申请公布日期 |
2013.06.27 |
申请号 |
CA20122853689 |
申请日期 |
2012.11.02 |
申请人 |
NITTO DENKO CORPORATION |
发明人 |
KNOPOV, VICTOR;WITTE, RICHARD P.;KARMALI, PRIYA;LEE, ROBIN;WEBB, DAVID;AKOPIAN, VIOLETTA |
分类号 |
A61K9/127;C12N15/113 |
主分类号 |
A61K9/127 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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