| 摘要 |
FIELD: medicine, pharmaceutics.SUBSTANCE: invention refers to new compounds of formula I, enantiomers and pharmaceutically acceptable salts thereof having the properties of AKT/protein kinase inhibitors. In formula 1G represents phenyl, naphthalene, 5-member heteroaryl with 1 sulphur atom in a ring or 9-member bicyclic heteroaryl specified in indolyl wherein phenyl, naphthalene, 5-member heteroaryl is optionally substituted by one of three Rgroups; Rand Rare independently specified in H, Me, Et, -CHOH, CF, CHFor CHF; Rrepresents H, -OH, -OMe or F; RrepresentsH, Me or F; Rrepresents H, Me, Et; Rrepresents H, 6-member heterocyclyl containing an oxygen atom as a heteroatom, cyclopropyl methyl or C-Calkyl is optionally substituted F,-OH or -O(C-Calkyl); Rand Rare independently specified in H and C-Calkyl, or Rand Rtogether with an atom whereto attached form a carbonyl group or 5-6-member cycloalkyl; each Rindependently represents halogen, C-C-alkyl, C-C-cycloalkyl,-O-(C-C-alkyl), CF, CN, phenyl, pyrazole, CHF, CHF, -OCHF, -OCHF, -OH, -SO(C-C-alkyl), C(O)NH; and j represents 1 or 2; and provided j represents 2, j-ring carbon atom, opposite NR, may be substituted by heteroatom O.EFFECT: compounds may be used for treating hyperproliferative diseases, such as cancer.35 cl, 9 dwg, 4 tbl, 141 ex |
