| 摘要 |
FIELD: medicine, pharmaceutics.SUBSTANCE: modified release pharmaceutical composition of bupropion hydrobromide contains a core with a therapeutically effective amount of bupropion hydrobromide and a controlled release polymeric coating. The coating contains a water-insoluble polymer in an amount of 1 wt % to 12 wt % of tablet weight and a water-soluble polymer in an amount of 1.5 wt % to 10 wt % of weight tablet. The above coating surrounds the core at least partially. The composition releases bupropion hydrobromide in a dissolution medium containing 0.1N HCl and 5%-40 vol % of ethanol at a rate of approximately 1.1 or less than a release rate of bupropion hydrobromide from a modified-release similar pharmaceutical composition in a dissolution medium containing 0,1N HCl, measured over the range of time at least from 0 to 2 hours by means of type I USP apparatus at 75 rpm and at 37 ±5°C.EFFECT: invention provides a reduction in the alcohol-caused dose fall (drop) of bupropion hydrobromide.9 cl, 55 dwg, 46 tbl, 3 ex |
