发明名称 |
QUANTITATIVE PHASE MICROSCOPY FOR LABEL-FREE HIGH-CONTRAST CELL IMAGING USING FREQUENCY DOMAIN PHASE SHIFT |
摘要 |
Some systems described herein include a frequency dependent phase plate for generating multiple phase-contrast images of a sample, each from a different frequency range of light, each phase-contrast image for frequency range of light formed from light diffracted by the sample interfered with undiffracted light that has a frequency-dependent baseline relative phase shift from the phase plate. In some embodiments, the multiple phase-contrast images may be used to generate a quantitative phase image of a sample. The phase-contrast images or the produced quantitative phase image may have sufficient contrast for label-free auto-segmentation of cell bodies and nuclei.
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申请公布号 |
US2013162800(A1) |
申请公布日期 |
2013.06.27 |
申请号 |
US201213663043 |
申请日期 |
2012.10.29 |
申请人 |
GENERAL ELECTRIC COMPANY;GENERAL ELECTRIC COMPANY |
发明人 |
KIM EVGENIA MIKHAILOVNA;CHALLENER WILLIAM ALBERT;DYLOV DMITRY VLADIMIROVICH |
分类号 |
H04N7/18 |
主分类号 |
H04N7/18 |
代理机构 |
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代理人 |
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地址 |
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