发明名称 Use of monomycolyl glycerol (mmg) homologues, analogues for preparing an adjuvant or immunomodulator, the adjuvant or immunomodulator, a vaccine comprising the adjuvant or immunomodulator and a delivery system comprising the adjuvant or immunomodulator
摘要 <p>Here we identify MMG and its alpha- and ketomycolic acid derivatives as highly bioactive lipids derived from M. bovis BCG (Copenhagen) capable of stimulating and activating human DC's at exceedingly low doses. In addition to their direct role as immunostimulators of human DC's we demonstrate their use in the development of a new generation of adjuvants suitable for human administration. We furthermore identify a number of highly active synthetic MMG analogues with great potential in cancer treatment, and for vaccine adjuvants against both infectious disease and disorders like Alzheimers disease.</p>
申请公布号 IL203016(A) 申请公布日期 2013.06.27
申请号 IL20090203016 申请日期 2009.12.29
申请人 STATENS SERUM INSTITUT 发明人
分类号 A61K;A61P 主分类号 A61K
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