发明名称 |
BISPECIFIC T-CELL ACTIVATOR ANTIBODY |
摘要 |
<p>This invention relates to bispecific antibodies having combinations of linker and hinge sequences to create linker-hinge interface domains with biological significance. Such linker-hinge interface domains covalently join two molecules, maintain the biological activities of linked molecules (target binding), stabilize the biological characteristics of new molecule (solubility and 4°C stability), maintain the chemical, biochemical and physical properties (cytotoxicity) of the linked molecules, and modulate the biological characteristics of the linked molecules (activating T-lymphocytes without significant sign of proliferations). Both linker (GGGGS) and hinge (CPPCP) sequences are required to establish functional linker-hinge interface domains as deletion of any of the component resulted in significant lost of T-lymphocyte mediated activity.</p> |
申请公布号 |
WO2013096346(A1) |
申请公布日期 |
2013.06.27 |
申请号 |
WO2012US70432 |
申请日期 |
2012.12.19 |
申请人 |
DEVELOPMENT CENTER FOR BIOTECHNOLOGY;DCB-USA LLC |
发明人 |
HSU, YU-SHEN;SHEU, SHOW-SHAN;CHANG, MINGI;CHANG, MING-CHUAN;YUAN, TA-TUNG |
分类号 |
C07K16/46;A61K39/395;C07K16/18 |
主分类号 |
C07K16/46 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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